A dual inhibitor of ULK1 and ULK2
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SBP-7455

Item No. 32988

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)-2,4-pyrimidinediamine
CAS Number
1884222-74-5
Molecular Formula
C16H17F3N4O2
Formula Weight
354.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 1 mg/ml
λmax
221, 276 nm
SMILES
FC(F)(C1=CN=C(NC2=CC=C(C(OC)=C2)OC)N=C1NC3CC3)F
InChi Code
InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
InChi Key
BQROJYIEHOOQBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $174

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    10 mg

    $290

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    25 mg

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    Product Description

    SBP-7455 is a dual inhibitor of unc-51-like autophagy activating kinase 1 (ULK1) and ULK2 (IC50s = 13 and 476 nM, respectively, for the recombinant human enzymes in cell-free assays).1 It inhibits increases in autophagic flux and induces apoptosis in serum-deprived MDA-MB-468 breast cancer cells when used at a concentration of 10 µM. SBP-7455 (0.19 µM), alone or in combination with olaparib (Item No. 10621), reduces the viability of MDA-MB-468 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, H., Bakas, N.A., Vamos, M., et al. Design, synthesis, and characterization of an orally active dual-specific ULK1/2 autophagy inhibitor that synergizes with the PARP inhibitor olaparib for the treatment of triple-negative breast cancer. J. Med. Chem. 63(23), 14609-14625 (2020).