A bacterial metabolite with diverse biological activities
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Carbazomycin A

Item No. 33088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dimethoxy-1,2-dimethyl-9H-carbazol
CAS Number
75139-39-8
Molecular Formula
C16H17NO2
Formula Weight
255.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
COC(C(C)=C(C)C1=C2C3=C(C=CC=C3)N1)=C2OC
InChi Code
InChI=1S/C16H17NO2/c1-9-10(2)15(18-3)16(19-4)13-11-7-5-6-8-12(11)17-14(9)13/h5-8,17H,1-4H3
InChi Key
CABZEVNLYSXBGW-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It is active against S. aureus, T. asteroides, and T. mentagrophytes (MIC = 12.5 µg/ml for all), as well as the plant pathogenic fungus P. oryzae (MIC = 25 µg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 µg/ml, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakano, K.-I., Ishimaru, K., and Nakamura, S. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot. (Tokyo) 33(7), 683-689 (1980).

    2. Intaraudom, C., Rachtawee, P., Suvannakad, R., et al. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924. Tetrahedron 67(39), 7593-7597 (2011).