A TLR4 antagonist
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T-5342126

Item No. 33099

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[[1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]methyl]methylamino]-3-(4-ethoxyphenoxy)-2-propanol
CAS Number
956507-49-6
Molecular Formula
C25H32ClN3O3
Formula Weight
458.0
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: 10 mg/ml
SMILES
CN(CC(COC1=CC=C(C=C1)OCC)O)CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C
InChi Code
InChI=1S/C25H32ClN3O3/c1-5-31-22-10-12-23(13-11-22)32-17-21(30)15-28(4)16-24-18(2)27-29(19(24)3)14-20-8-6-7-9-25(20)26/h6-13,21,30H,5,14-17H2,1-4H3
InChi Key
UOKIJOWYTBNPIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1 It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chavez, S.A., Martinko, A.J., Lau, C., et al. Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics. J. Med. Chem. 54(13), 4659-4669 (2011).

    2. Bajo, M., Montgomery, S.E., Cates, L.N., et al. Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent mice. Alcohol Alcohol. 51(5), 541-548 (2016).