A muscarinic acetylcholine receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Procyclidine (hydrochloride)

Item No. 33141

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-cyclohexyl-α-phenyl-1-pyrrolidinepropanol, monohydrochloride
CAS Number
1508-76-5
Molecular Formula
C19H29NO • HCl
Formula Weight
323.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
SMILES
OC(CCN1CCCC1)(C2CCCCC2)C3=CC=CC=C3.Cl
InChi Code
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
InChi Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $79

    Add

    1 g

    $140

    Add

    5 g

    $659

    Add
    Product Description

    Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively).1 It increases fine motor activity counts (ED50 = 1.74 mg/kg) without affecting ambulatory activity in rats in a home-cage activity test.2 Formulations containing procyclidine have been used in the treatment of parkinsonism and extrapyramidal dysfunction.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lazareno, S., Buckley, N.J., and Roberts, F.F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cell. Mol. Pharmacol. 38(6), 805-815 (1990).

    2. Sipos, M.L., Burchnell, V., and Galbicka, G. Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats. Psychopharmacology 147(3), 250-256 (1999).