A muscarinic acetylcholine receptor antagonist
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Procyclidine (hydrochloride)

Item No. 33141

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-cyclohexyl-α-phenyl-1-pyrrolidinepropanol, monohydrochloride
CAS Number
1508-76-5
Molecular Formula
C19H29NO • HCl
Formula Weight
323.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
SMILES
OC(CCN1CCCC1)(C2CCCCC2)C3=CC=CC=C3.Cl
InChi Code
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
InChi Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $79

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    1 g

    $140

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    5 g

    $659

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    Product Description

    Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively).1 It increases fine motor activity counts (ED50 = 1.74 mg/kg) without affecting ambulatory activity in rats in a home-cage activity test.2 Formulations containing procyclidine have been used in the treatment of parkinsonism and extrapyramidal dysfunction.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lazareno, S., Buckley, N.J., and Roberts, F.F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cell. Mol. Pharmacol. 38(6), 805-815 (1990).

    2. Sipos, M.L., Burchnell, V., and Galbicka, G. Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats. Psychopharmacology 147(3), 250-256 (1999).