(+)-Secoisolariciresinol

(+)-Secoisolariciresinol ((+)-SECO) is a lignan that has been found in flaxseed and has diverse biological activities.^1,2,3 It inhibits α-glucosidase and α-amylase in a cell-free assay when used at a concentration of 20 µM.¹ (+)-SECO (0.3 mM) reduces adiponectin production by, and triglyceride accumulation in, 3T3-L1 adipocytes.² It stimulates IgM production in HB4C5 hybridoma cells when used at concentrations ranging from 0.1 to 100 µM.³

WARNING This product is not for human or veterinary use.

1. Hano, C., Renouard, S., Molinié, R., et al. Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity. Bioorg. Med. Chem. Lett. 23(10), 3007-3012 (2013).

2. Tominaga, S., Sugahara, T., Nishimoto, S., et al. The effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and activity. Biosci. Biotechnol. Biochem. 73(1), 35-39 (2009).

3. Sugahara, T., Yamauchi, S., Nishimoto, S., et al. The structure-activity relationships of flaxseed lignan, secoisolariciresinol. Interdisciplinary Studies on Environmental Chemistry 263-268 (2008).