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N-Piperidinyl Etonitazene (citrate)

Item No. 33168

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Etonitazepipne
  • N-Piperidyl Etonitazene
Technical Information
Formal Name
2-[(4-ethoxyphenyl)methyl]-5-nitro-1-[2-(1-piperidinyl)ethyl]-1H-benzimidazole, 2-hydroxy-1,2,3-propanetricarboxylate
Molecular Formula
C23H28N4O3 • C6H8O7
Formula Weight
600.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
241 nm
SMILES
CCOC(C=C1)=CC=C1CC2=NC3=CC([N+]([O-])=O)=CC=C3N2CCN4CCCCC4.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C23H28N4O3.C6H8O7/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25;7-3(8)1-6(13,5(11)12)2-4(9)10/h6-11,17H,2-5,12-16H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
SHOWCAJXNDOKRF-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    N-Piperidinyl etonitazene (citrate) (Item No. 33168) is an analytical reference standard categorized as an opioid.1 N-Piperidinyl etonitazene induces antinociceptive effects in mice in the hot plate test. N-Piperidinyl etonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vandeputte, M.M., Verougstraete, N., Walther, D., et al. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass. Arch. Toxicol. 96(6), 1865-1880 (2022).

    Product Citations

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Kozell, L.B., Eshelman, A., J., Wolfrum, K.M., et al. Pharmacologic characterization of substituted nitazenes at μ, κ, and Δ opioid receptors suggests high potential for toxicity. J. Pharmacol. Exp. Ther. 389(2), 219-228 (2024).

    Tsai, M.-H.M., Chen, L., Baumann, M.H., et al. In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chem. Neurosci. 15(4), 854-867 (2024).

    Vandeputte, M.M., Verougstraete, N., Walther, D., et al. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass. Arch. Toxicol. 96(6), 1865-1880 (2022).