A triterpenoid saponin with diverse biological activities
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Isomer(s)
11822Bacopaside II 11824Bacoside A3
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Asperosaponin VI

Item No. 33206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α)-3-(α-L-arabinopyranosyloxy)-23-hydroxy-olean-12-en-28-oic acid, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester
CAS Number
39524-08-8
Synonyms
  • Akebia Saponin D
  • ASA VI
  • Leiyemudanoside A
  • Tauroside St-G0-1
Molecular Formula
C47H76O18
Formula Weight
929.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC([C@]34[C@](CC(C)(CC4)C)([H])C5=CC[C@@]([C@@]6([C@@]([C@@](C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O)CO)([H])CC8)C)([H])[C@]8(C)[C@@]5(CC3)C)=O
InChi Code
InChI=1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1
InChi Key
CCRXMHCQWYVXTE-HMRSNRLKSA-N
Origin
Plant/Dipsacus fullonum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $75

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    50 mg

    $333

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    100 mg

    $589

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    Product Description

    Asperosaponin VI is a triterpenoid saponin that has been found in D. asper and has diverse biological activities.1,2,3 It increases bone morphogenetic protein 2 (BMP2) levels in, and induces differentiation of, MC3T3-E1 mouse preosteoblasts in a concentration-dependent manner.1 It also inhibits osteoclast formation induced by RANKL in vitro and reduces joint inflammation and bone loss in a mouse model of collagen-induced arthritis when administered at a dose of 20 mg/kg.2 Asperosaponin VI (150 and 450 mg/kg) reduces increases in acetic acid-induced vascular permeability and increases the latency to paw withdrawal in the hot plate test in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niu, Y., Li, Y., Huang, H., et al. Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase ½ pathway. Phytother. Res. 25(11), 1700-1706 (2011).

    2. Liu, K., Liu, Y., Xu, Y., et al. Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis. Phytomedicine 63, 153006 (2019).

    3. Gong, L.-L., Yang, S., Liu, H., et al. Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D. Eur. J. Pharmacol. 845, 85-90 (2019).