An antioxidant and P-gp inhibitor
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Isomer(s)
33206Asperosaponin VI
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Bacoside A3

Item No. 11824

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-α-L-arabinofuranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside
CAS Number
157408-08-7
Synonyms
  • Bacopa Pgp
Molecular Formula
C47H76O18
Formula Weight
929.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly, sonicatedPyridine: slightly soluble
SMILES
C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O[C@H]7[C@@H]([C@H]([C@@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)CO)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(O[C@H](C[C@@]9(O)C)/C=C(C)\C)C3
InChi Code
InChI=1S/C47H76O18/c1-21(2)14-22-15-45(7,57)38-23-8-9-28-43(5)12-11-29(42(3,4)27(43)10-13-44(28,6)46(23)19-47(38,65-22)58-20-46)62-41-37(64-39-34(55)31(52)25(17-49)60-39)36(32(53)26(18-50)61-41)63-40-35(56)33(54)30(51)24(16-48)59-40/h14,22-41,48-57H,8-13,15-20H2,1-7H3/t22-,23+,24+,25-,26+,27-,28+,29-,30+,31-,32+,33-,34+,35+,36-,37+,38-,39-,40-,41-,43-,44+,45-,46-,47-/m0/s1
InChi Key
CDEVGTJBRPBOPH-INTDMYAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $636

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    Product Description

    Bacoside A3 is a triterpenoid saponin first isolated from B. monniera.1 Bacoside A3 inhibits the ATP-binding cassette transporter P-glycoprotein (P-gp), decreasing efflux 4-fold compared with control in vitro.2 An extract containing bacoside A3 and bacopaside II (4 and 1.3 µg/mg extract, respectively) administered for eight days at a dose of 10-30 mg/kg reduces opioid withdrawal-induced depression in mice using the forced swim test.3 Bacoside A3 also has antioxidant properties following liver and kidney damage induced by street heroin in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rastogi, S., Pal, R., and Kulshreshtha, D.K. Bacoside A3--a triterpenoid saponin from Bacopa monniera. Phytochemistry 36(1), 133-137 (1994).

    2. Singh, R., Rachumallu, R., Bhateria, M., et al. In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity. Xenobiotica 45(8), 741-749 (2015).

    3. Rauf, K., Subhan, F., Abbas, M., et al. Inhibitory effect of bacopasides on spontaneous morphine withdrawal induced depression in mice. Phytother. Res. 28(6), 937-939 (2014).

    4. Shahid, M., Subhan, F., Ullah, I., et al. Beneficial effects of Bacopa monnieri extract on opioid induced toxicity. Heliyon 2(2), e00068 (2016).