A prodrug form of the antiviral baloxavir acid
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Active Metabolite(s)
35125Baloxavir
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Baloxavir Marboxil

Item No. 33214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]-carbonic acid, methyl ester
CAS Number
1985606-14-1
Synonyms
  • BXM
  • S-033188
Molecular Formula
C27H23F2N3O7S
Formula Weight
571.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
λmax
259 nm
SMILES
O=C1N(CCOC2)[C@]2([H])N([C@H]3C4=CC=C(F)C(F)=C4CSC5=CC=CC=C53)N(C=CC6=O)C1=C6OCOC(OC)=O
InChi Code
InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1
InChi Key
RZVPBGBYGMDSBG-GGAORHGYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Baloxavir marboxil is a prodrug form of the antiviral and influenza virus cap-dependent endonuclease (CEN) inhibitor baloxavir acid.1,2 It inhibits influenza CEN and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activity in cell-free assays (IC50s = 530 and 340 nM, respectively).2 Baloxavir marboxil prevents mortality in a mouse model of influenza A and B viral infection when administered at a dose of 5 or 50 mg/kg twice in a single day.1 It also reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg. Formulations containing baloxavir marboxil have been used in the early treatment of uncomplicated influenza.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukao, K., Ando, Y., Noshi, T., et al. Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models. PLoS One 14(5), e0217307 (2019).

    2. Noshi, T., Kitano, M., Taniguchi, K., et al. In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit. Antiviral Res. 160, 109-117 (2017).