An active metabolite of baloxavir marboxil
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Pro-drug Form(s)
33214Baloxavir Marboxil
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Baloxavir

Item No. 35125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-tetrahydro-7-hydroxy-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione
CAS Number
1985605-59-1
Synonyms
  • BXA
  • S-033447
Molecular Formula
C24H19F2N3O4S
Formula Weight
483.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/ml
λmax
260 nm
SMILES
O=C1C(N(C=C2)N([C@@H]3C4=CC=CC=C4SCC5=C(F)C(F)=CC=C53)[C@@]6([H])N1CCOC6)=C(O)C2=O
InChi Code
InChI=1S/C24H19F2N3O4S/c25-16-6-5-13-15(20(16)26)12-34-18-4-2-1-3-14(18)21(13)29-19-11-33-10-9-27(19)24(32)22-23(31)17(30)7-8-28(22)29/h1-8,19,21,31H,9-12H2/t19-,21+/m1/s1
InChi Key
FIDLLEYNNRGVFR-CTNGQTDRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Baloxavir is an active metabolite of baloxavir marboxil (Item No. 33214).1 It inhibits influenza virus cap-dependent endonuclease (CEN) and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activities in cell-free assays (IC50s = 2.5 and 1.6 nM, respectively). Baloxavir reduces viral titers in MDCK cells infected with laboratory, clinical, or zoonotic strains of influenza A or B (EC50s = 0.46-6.5 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noshi, T., Kitano, M., Taniguchi, K., et al. In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit. Antiviral Res. 160, 109-117 (2017).