An internal standard for the quantification of pentoxifylline
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Unlabeled Version(s)
18720Pentoxifylline
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Pentoxifylline-d6

Item No. 33244

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-3,7-di(methyl-d3)-1-(5-oxohexyl)-1H-purine-2,6-dione
CAS Number
1185878-98-1
Synonyms
  • Oxpentifylline-d6
Molecular Formula
C13H12D6N4O3
Formula Weight
284.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
O=C1C2=C(N=CN2C([2H])([2H])[2H])N(C(N1CCCCC(C)=O)=O)C([2H])([2H])[2H]
InChi Code
InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3/i2D3,3D3
InChi Key
BYPFEZZEUUWMEJ-XERRXZQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $248

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    5 mg

    $990

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    Product Description

    Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline (Item No. 18720) by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent.1 It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM.2 Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood.3 It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg/kg.4 Formulations containing pentoxifylline have been used in the treatment of intermittent claudication.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ward, A., and Clissold, S.P. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34(1), 50-97 (1987).

    2. Słoczyńska, K., Kózka, M., Pękala, E., et al. In vitro effect of pentoxifylline and lisofylline on deformability and aggregation of red blood cells from healthy subjects and patients with chronic venous disease. Acta Biochim. Pol. 60(1), 129-135 (2013).

    3. Magnusson, B., Gunnarsson, M., Berntorp, E., et al. Effects of pentoxifylline and its metabolites on platelet aggregation in whole blood from healthy humans. Eur. J. Pharmacol. 581(3), 290-295 (2008).

    4. Michal, M., Giessinger, N., and Schröer, R. Reduced thrombus formation in vivo after administration of pentoxifylline (Trental). Thromb. Res. 56(3), 359-368 (1989).