An antagonist of UTR
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SB-611812

Item No. 33247

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)-benzenesulfonamide
CAS Number
345892-71-9
Molecular Formula
C17H16Cl3F3N2O3S
Formula Weight
491.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mMDMSO: 10 mM
SMILES
O=S(NC1=CC=C(C(OCCN(C)C)=C1)Cl)(C2=C(C=C(C(F)(F)F)C=C2Cl)Cl)=O
InChi Code
InChI=1S/C17H16Cl3F3N2O3S/c1-25(2)5-6-28-15-9-11(3-4-12(15)18)24-29(26,27)16-13(19)7-10(8-14(16)20)17(21,22)23/h3-4,7-9,24H,5-6H2,1-2H3
InChi Key
UIZHOFJFIOCYLH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $213

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    Product Description

    SB-611812 is an antagonist of the urotensin II receptor (UTR).1 It binds to recombinant rat UTR (Ki = 121 nM) and inhibits contraction of isolated rat aorta induced by urotensin II (pA2 = 6.59) but not potassium chloride, endothelin-1, angiotensin II, or phenylephrine. SB-611812 (30 mg/kg) decreases myocardial interstitial fibrosis and the ratio of collagen I to collagen III in a rat model of ischemia induced by ligation of the left anterior descending (LAD) artery.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rakowski, E., Hassan, G.S., Dhanak, D., et al. A role for urotensin II in restenosis following balloon angioplasty: Use of a selective UT receptor blocker. J. Mol. Cell. Cardiol. 39(5), 785-791 (2005).

    2. Bousette, N., Pottinger, J., Ramli, W., et al. Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27(11), 2919-2926 (2006).