N^G,N^G-dimethyl-L-Arginine-d₆ (hydrochloride)

N^G,N^G-dimethyl-L-arginine-d₆ (ADMA-d₆) (hydrochloride) is intended for use as an internal standard for the quantification of N^G,N^G-dimethyl-L-arginine (Item No. 80230) by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS).^1,2 It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2).¹ ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet.² ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.^1,3,4

WARNING This product is not for human or veterinary use.

1. Sydow, K., and Münzel, T. ADMA and oxidative stress. Atheroscler. Suppl. 4(4), 41-51 (2003).

2. Jin, J.S., and D'Alecy, L.G. Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor. J. Cardiovasc. Pharmacol. 28(3), 439-446 (1996).

3. Vallance, P., Leone, A., Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339(8793), 572-575 (1992).

4. Matsuoka, H., Itoh, S., Kimoto, M., et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 29(1 Pt 2), 242-247 (1997).