An endogenous NOS inhibitor
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Labeled Version(s)
33266NG,NG-dimethyl-L-Arginine-d6 (hydrochloride)
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NG,NG-dimethyl-L-Arginine (hydrochloride)

Item No. 80230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride
CAS Number
220805-22-1
Synonyms
  • ADMA
  • Asymmetric dimethylarginine
Molecular Formula
C8H18N4O2 • 2HCl
Formula Weight
275.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 20 mg/mlWater: 20 mg/ml
SMILES
OC(=O)[C@@H](N)CCCNC(=N)N(C)C
InChi Code
InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)
InChi Key
YDGMGEXADBMOMJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $50

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    25 mg

    $118

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    50 mg

    $205

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    Product Description

    NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS).1,2 It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2).1 ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet.2 ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.1,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sydow, K., and Münzel, T. ADMA and oxidative stress. Atheroscler. Suppl. 4(4), 41-51 (2003).

    2. Jin, J.S., and D'Alecy, L.G. Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor. J. Cardiovasc. Pharmacol. 28(3), 439-446 (1996).

    3. Vallance, P., Leone, A., Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339(8793), 572-575 (1992).

    4. Matsuoka, H., Itoh, S., Kimoto, M., et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 29(1 Pt 2), 242-247 (1997).