A potent 5-HT2C receptor agonist
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Alternative(s)
24214CP 809,101
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CP 809,101 (hydrochloride)

Item No. 33283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-pyrazine, monohydrochloride
CAS Number
1215721-40-6
Molecular Formula
C15H17ClN4O • HCl
Formula Weight
341.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100mMWater: 20mM
λmax
248, 326 nm
SMILES
ClC1=CC=CC(COC2=CN=CC(N3CCNCC3)=N2)=C1.Cl
InChi Code
InChI=1S/C15H17ClN4O.ClH/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20;/h1-3,8-10,17H,4-7,11H2;1H
InChi Key
NMUNRTCTDLORDR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

    $688

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    Cayman Chemical
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    Product Description

    CP 809,101 is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT2C.1 It is selective for human 5-HT2C and rat 5-HT2C over human 5-HT2A, 5-HT2B, and rat 5-HT2A receptors in a FLIPR membrane potential assay (EC50s = 0.11, 0.06, 153, 65.3, and 119 nM, respectively) as well as human dopamine D2, histamine H1, and α1- and α2-adrenergic receptors (Kis = 872, 828, 217, and 956 nM, respectively). CP 809,101 inhibits the conditioned avoidance response, hyperactivity induced by PCP and D-amphetamine, and spontaneous locomotor activity in rats (ED50s = 4.8, 2.4, 2.9, and 2 mg/kg, respectively). It reduces prepulse inhibition deficits induced by apomorphine and improves novel object recognition in mice. CP 809,101 (0.01-1 μg/0.2 μl/side) reduces reinstatement of drug-seeking behavior in cocaine-primed rats when administered into the central amygdala but not the basolateral amygdala.2 It also reduces reinstatement of food-seeking behavior in a rat model of dietary relapse.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Siuciak, J.A., Chapin, D.S., McCarthy, S.A., et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology 52(2), 279-290 (2007).

    2. Pockros-Burgess, L.A., Pentkowski, N.S., Der-Ghazarian, T., et al. Effects of the 5-HT2C receptor agonist CP809101 in the amygdala on reinstatement of cocaine-seeking behavior and anxiety-like behavior. Int. J. Neuropsychopharmacol. 17(11), 1751-1762 (2014).

    3. Higgins, G.A., Silenieks, L.B., Altherr, E.B., et al. Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists. Psychopharmacology (Berl) 233(14), 2841-2856 (2016).