An internal standard for the quantification of propafenone
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Unlabeled Version(s)
21871Propafenone (hydrochloride)
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Propafenone-d5 (hydrochloride)

Item No. 33293

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-(2-hydroxy-3-(propylamino)propoxy-1,1,2,3,3-d5)phenyl)-3-phenylpropan-1-one, monohydrochloride
CAS Number
1346605-05-7
Molecular Formula
C21H22D5NO3 • HCl
Formula Weight
382.9
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
CCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=C(C=CC=C1)C(CCC2=CC=CC=C2)=O.Cl
InChi Code
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H/i15D2,16D2,18D;
InChi Key
XWIHRGFIPXWGEF-FIFLIBHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Propafenone-d5 is intended for use as an internal standard for the quantification of propafenone (Item No. 21871) by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent.1 It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively).1,2 Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.2,3,4 In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.5 Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Delgado, C., Tamargo, J., D., H., et al. Effects of propafenone on calcium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 108(3), 721-727 (1993).

    2. Christé, G., Tebbakh, H., Šimurdová, M., et al. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Eur. J. Pharmacol. 373(2-3), 223-232 (1999).

    3. Delpón, E., Valenzuela, C.F., Pérez, O., et al. Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component. Circ. Res. 76(2), 223-235 (1995).

    4. Aoyama, K., Ishikuro, E., Noriduki, H., et al. Formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of Fusarium semitectum on sorghum and ratios in naturally contaminated sorghum. Food Hyg. Saf. Sci. 56(6), 247-251 (2015).

    5. Germiniani, H., and Germiniani, C. Effect of propafenone hydrochloride in ventricular arrhythmias experimentally induced by barium chloride. Arq. Bras. Cardiol. 36(2), 101-105 (1981).