A class I antiarrhythmic agent
Related Products
Active Metabolite(s)
430785-Hydroxypropafenone (hydrochloride)
Analytical Standard(s)
44945Propafenone (hydrochloride)
Labeled Version(s)
33293Propafenone-d5 (hydrochloride)
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Propafenone (hydrochloride)

Item No. 21871

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride
CAS Number
34183-22-7
Molecular Formula
C21H27NO3 • HCl
Formula Weight
377.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.3 mg/ml
λmax
209, 247, 303 nm
SMILES
O=C(C1=CC=CC=C1OCC(CNCCC)O)CCC2=CC=CC=C2.Cl
InChi Code
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChi Key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

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    10 g

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    Product Description

    Propafenone is a class I antiarrhythmic agent.1 It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively).1,2 Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.2,3,4 In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.5 Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Delgado, C., Tamargo, J., D., H., et al. Effects of propafenone on calcium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 108(3), 721-727 (1993).

    2. Christé, G., Tebbakh, H., Šimurdová, M., et al. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Eur. J. Pharmacol. 373(2-3), 223-232 (1999).

    3. Delpón, E., Valenzuela, C.F., Pérez, O., et al. Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component. Circ. Res. 76(2), 223-235 (1995).

    4. Simó-Vicens, R., Sauter, D.R.P., Grunnet, M., et al. Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels. Eur. J. Pharmacol. (2017).

    5. Germiniani, H., and Germiniani, C. Effect of propafenone hydrochloride in ventricular arrhythmias experimentally induced by barium chloride. Arq. Bras. Cardiol. 36(2), 101-105 (1981).