An anti-integrin peptide
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Risuteganib (trifluoroacetate salt)

Item No. 33303

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-arginylglycyl-3-sulfo-L-alanyl-L-threonyl-L-proline, trifluoroacetate salt
Synonyms
  • ALG-1001
Molecular Formula
C22H39N9O11S • XCF3COOH
Formula Weight
637.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
N=C(N)NCCC[C@H](NC(CN)=O)C(NCC(N[C@@H](CS(O)(=O)=O)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C22H39N9O11S.C2HF3O2/c1-11(32)17(20(37)31-7-3-5-14(31)21(38)39)30-19(36)13(10-43(40,41)42)29-16(34)9-27-18(35)12(28-15(33)8-23)4-2-6-26-22(24)25;3-2(4,5)1(6)7/h11-14,17,32H,2-10,23H2,1H3,(H,27,35)(H,28,33)(H,29,34)(H,30,36)(H,38,39)(H4,24,25,26)(H,40,41,42);(H,6,7)/t11-,12+,13+,14+,17+;/m1./s1
InChi Key
WLTGXURCDLTUBR-CIEQAUARSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

    $328

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    10 mg

    $609

    Add
    Product Description

    Risuteganib is an anti-integrin peptide and a derivative of RGD peptide (Item No. 14501).1 Risuteganib (400 µM) protects against hydroquinone-induced necrosis and apoptosis, as well as inhibits hydroquinone-induced production of reactive oxygen species (ROS), in human retinal pigment epithelial (RPE) cells.2 It decreases the expression of BAX, VEGFA, and ITB1 in human age-related macular degeneration (AMD) cybrid cell lines when used at a concentration of 20 mg/ml.3 Risuteganib arrests aberrant blood vessel growth mediated by αVβ3, αVβ5, and α5β1 integrins in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaiser, P., Boyer, D.D., Campochiaro, P.A., et al. Integrin peptide therapy: The first wet AMD experience. Invest. Opth. Vis. Sci. 54(15), 2177 (2013).

    2. Yang, P., Shao, Z., Besley, N.A., et al. Risuteganib protects against hydroquinone-induced injury in human RPE cells. Invest. Ophthalmol. Vis. Sci. 61(10), 35 (2020).

    3. Schneider, K., Chwa, M., Atilano, S.R., et al. Differential effects of risuteganib and bevacizumab on AMD cybrid cells. Exp. Eye Res. 203, 108287 (2021).