An isoxazoline insecticide and acaricide
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Afoxolaner

Item No. 33317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
CAS Number
1093861-60-9
Molecular Formula
C26H17ClF9N3O3
Formula Weight
625.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
212, 221 nm
SMILES
O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(Cl)=CC(C(F)(F)F)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O
InChi Code
InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)
InChi Key
OXDDDHGGRFRLEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

    $275

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    Cayman Chemical
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    Product Description

    Afoxolaner is an isoxazoline insecticide and acaricide.1 It is a GABA receptor antagonist that inhibits GABA-induced currents in P. americana thoracic neurons (IC50 = 10.8 nM). It induces mortality in 100% of C. felis after 24 and 48 hours when used at concentrations of 0.32 and 0.16 µg/ml in an artificial membrane blood feeding device. Afoxolaner (2.5 mg/kg) eradicates C. felis infestation in dogs for up to 42 days and D. variabilis infestation for up to 30 days.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoop, W.L., Hartline, E.J., Gould, B.R., et al. Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Vet. Parasitol. 201(3-4), 179-189 (2014).