CP94

CP94 is an iron chelator.¹ It enhances protoporphyrin IX photobleaching and decreases in the viability of A431 squamous epithelial carcinoma cells when used at a concentration of 150 µM in combination with photodynamic therapy (PDT) mediated by the protoporphyrin IX precursors aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate (HAL; Item No. 23949).² CP94 (2 mg/ml in the drinking water) decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice.³ It also reduces ferrocene-induced increases in rat brain iron levels when administered at a dose of 100 mg/kg.⁴

WARNING This product is not for human or veterinary use.

1. Dobbin, P.S., Hider, R.C., Hall, A.D., et al. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential. J. Med. Chem. 36(17), 2448-2458 (1993).

2. Blake, E., Allen, J., and Curnow, A. The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditions. Photodiagnosis Photodyn. Ther. 10(4), 575-582 (2013).

3. Smith, A.G., Clothier, B., Francis, J.E., et al. Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice. Blood 89(3), 1045-1051 (1997).

4. Ward, R.J., Dexter, D., Florence, A., et al. Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolism. Biochem. Pharmacol. 49(12), 1821-1826 (1995).