An antagonist of NPY receptor Y2
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SF11

Item No. 33355

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
CAS Number
443292-81-7
Molecular Formula
C27H30N2O2S
Formula Weight
446.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
252 nm
SMILES
S=C(N1CCC(C(C2=CC=CC=C2)(C3=CC=CC=C3)O)CC1)NC4=CC=C(C=C4)OCC
InChi Code
InChI=1S/C27H30N2O2S/c1-2-31-25-15-13-24(14-16-25)28-26(32)29-19-17-23(18-20-29)27(30,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,30H,2,17-20H2,1H3,(H,28,32)
InChi Key
PMEQBGAGFZDWQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $132

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    10 mg

    $242

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    Product Description

    SF11 is an antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50 = 0.199 µM).1 It is selective for Y2 over Y1 receptors (IC50 = >33 µM), as well as a panel of 40 additional receptors, ion channels, and transporters at 10 µM. SF11 (10 and 30 mg/kg) decreases immobility time in the forced swim test in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brothers, S.P., Saldanha, A., Spicer, T.P., et al. Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol. Pharmacol. 77(1), 46-57 (2010).

    2. Domin, H., Piergies, N., Pięta, E., et al. Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem. Neurosci. 10(8), 3454-3463 (2019).