Griseofulvin-d₃

Griseofulvin-d₃ is intended for use as an internal standard for the quantification of griseofulvin (Item No. 19461) by GC- or LC-MS. Griseofulvin is a fungal metabolite that has been found in Penicillium and has diverse biological activities.¹ It is active against clinical isolates of the dermatophytes T. rubrum, T. tonsurans, and M. canis (MICs = 0.0078-0.0156, 1-4, and 0.5-2 µg/ml, respectively).² Griseofulvin binds to tubulin (K_d = 300 µM) and reduces the growth rate and shortening rate of isolated bovine brain microtubulin, indicating stabilization of microtubule dynamics, when used at concentrations ranging from 0.5 to 20 µM.³ It induces abnormal microtubule polymerization and cell cycle arrest at the G₂/M phase in HT-29 cells when used at a concentration of 20 µM.⁴ Griseofulvin (30 mg/kg), alone or in combination with nocodazole (Item No. 13857), reduces tumor growth in a COLO 205 mouse xenograft model. Formulations containing griseofulvin have been used in the treatment of fungal infections.

WARNING This product is not for human or veterinary use.

1. Singh, P., Rathinasamy, K., Mohan, R., et al. Microtubule assembly dynamics: An attractive target for anticancer drugs. IUBMB Life 60(6), 368-375 (2008).

2. Brilhante, R.S.N., Correia, E.E.M., Guedes, G.M.M., et al. In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes. Mycoses 61(7), 449-454 (2018).

3. Panda, D., Rathinasamy, K., Santra, M.K., et al. Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer. Proc. Natl. Acad. Sci. USA 102(28), 9878-9883 (2005).

4. Ho, Y.-S., Duh, J.-S., Jeng, J.-H., et al. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G₂/M cell cycle arrest in human colorectal cancer cells. Int. J. Cancer 91(3), 393-401 (2001).