A glycine-site selective NMDA receptor antagonist
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7-Chlorokynurenic Acid

Item No. 33408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-4-hydroxy-2-quinolinecarboxylic acid
CAS Number
18000-24-3
Synonyms
  • 7-CKA
  • 7-CTKA
  • 7-chloro KYNA
  • NSC 149792
Molecular Formula
C10H6ClNO3
Formula Weight
223.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleEthanol: slightly soluble
λmax
223, 250, 340 nm
SMILES
O=C(C1=CC(O)=C2C=CC(Cl)=CC2=N1)O
InChi Code
InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
InChi Key
UAWVRVFHMOSAPU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $95

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    25 mg

    $214

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    50 mg

    $363

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    Product Description

    7-Chlorokynurenic acid is an NMDA receptor antagonist.1 It selectively binds to the NMDA receptor glycine-binding site (IC50 = 0.56 µM) over the NMDA-, quisqualate-, and kainate-binding sites (IC50s = 169, 153, and >1,000 µM, respectively). Intra-dorsal hippocampal administration of 7-chlorokynurenic acid (3.2 µg per side) increases the number of errors in a three-panel runway test of working memory, an effect that can be blocked by the NMDA glycine-site co-agonist D-serine (Item No. 31197).2 It also induces antidepressant-like activity in the forced swim test, novelty-suppressed feeding test, and a foot shock-based learned helplessness test in mice when administered at doses of 0.1 and 1 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kemp, J.A., Foster, A.C., Leeson, P.D., et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc. Natl. Acad. Sci. USA 85(17), 6547-6550 (1988).

    2. Ohno, M., Yamamoto, T., and Watanabe, S. Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats. Eur. J. Pharmacol. 253(1-2), 183-187 (1994).

    3. Zhu, W.-L., Wang, S.-J., Liu, M.-M., et al. Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats. J. Psychiatry Neurosci. 38(5), 306-316 (2013).