An endogenous metabolite of cortisol
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Parent Compound(s)
20739Hydrocortisone
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β-Cortol

Item No. 33412

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5β-pregnane-3α,11β,17,20R,21-pentol
CAS Number
667-65-2
Synonyms
  • NSC 58792
Molecular Formula
C21H36O5
Formula Weight
368.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: slightly solubleMethanol: slightly solublePyridine: soluble
SMILES
C[C@@]12[C@](CC[C@]2(O)[C@@H](CO)O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
InChi Code
InChI=1S/C21H36O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-18,22-26H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,17-,18-,19+,20+,21+/m1/s1
InChi Key
FFPUNPBUZDTHJI-ZFOKFBPFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $98

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    10 mg

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    25 mg

    $368

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    50 mg

    $686

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    Product Description

    β-Cortol is an endogenous metabolite of cortisol (hydrocortisone; Item No. 20739).1,2 It is formed from cortisol via the intermediate metabolite 5β-tetrahydrocortisol, which is dehydrogenated by 20β-hydroxysteroid dehydrogenase (20β-HSD) in the liver to produce β-cortol.2 Urinary levels of β-cortol have been used as a marker for cortisol production and are associated with metabolic syndrome in obese individuals.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krone, N., Hughes, B.A., Lavery, G.G., et al. Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS). J. Steroid Biochem. Mol. Biol. 121(3-5), 496-504 (2010).

    2. Schiffer, L., Barnard, L., Baranowski, E.S., et al. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. J. Steroid Biochem. Mol. Biol. 194, 105439 (2019).

    3. Baudrand, R., Campino, C., Carvajal, C.A., et al. Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction. Steroids 76(14), 1575-1581 (2011).