A flavone with diverse biological activities
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Kuwanon C

Item No. 33421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS Number
62949-79-5
Synonyms
  • Mulberrin
Molecular Formula
C25H26O6
Formula Weight
422.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
264 nm
SMILES
O=C1C2=C(C=C(C(C/C=C(C)\C)=C2OC(C3=C(O)C=C(O)C=C3)=C1C/C=C(C)\C)O)O
InChi Code
InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3
InChi Key
UWQYBLOHTQWSQD-UHFFFAOYSA-N
Origin
Plant/Morus root
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $351

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    25 mg

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    Product Description

    Kuwanon C is a prenylated flavone originally isolated from M. alba that has diverse biological activities, including antioxidant, antibacterial, antiproliferative, and neuroprotective properties.1 It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (EC50 = 72.99 µg/ml).2 It is active against E. coli, S. typhimurium, S. epidermis, and S. aureus (MICs = 10, 25, 6.25, and 6.25 µg/ml, respectively) and inhibits the growth of P388 mouse lymphoma cancer cells (IC50 = 14 µg/ml).3,4 Kuwanon C (30 mg/kg) improves motor coordination in a rotarod test and decreases neuronal loss in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nomura, T., Fukai, T., and Katayanagi, M. Kuwanon A, B, C and oxydihydromorusin, four new flavones from the root bark of the cultivated mulberry tree (Morus alba L.). Chem. Pharm. Bull. 25(3), 529-532 (1977).

    2. Mazimba, O., Majinda, R.R.T., and Motlhanka, D. Antioxidant and antibacterial constituents from Morus nigra. Afr. J. Pharma. Pharmaco. 5(6), 751-754 (2011).

    3. Sohn, H.-Y., Son, K.H., Kwon, C.-S., et al. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11(7-8), 666-672 (2004).

    4. Ferlinahayati, Syah, Y.M., Juliawaty, L.D., et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z. Naturforsch. C. J. Biosci. 63(1-2), 35-39 (2008).

    5. Cao, W., Dong, Y., Zhao, W., et al. Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson’s disease by promoting Wnt/β-catenin signaling pathway. J. Chem. Neuroanat. 98, 63-70 (2019).