A synthetic derivative of vitamin B1
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Fursultiamine

Item No. 33456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]-formamide
CAS Number
804-30-8
Synonyms
  • Fursultiamin
  • Thiamine Tetrahydrofurfuryl Disulfide
  • TTFD
Molecular Formula
C17H26N4O3S2
Formula Weight
398.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:9): 0.10 mg/mlEthanol: 1 mg/ml
λmax
236 nm
SMILES
O=CN(CC1=CN=C(C)N=C1N)C(C)=C(CCO)SSCC2CCCO2
InChi Code
InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20)
InChi Key
JTLXCMOFVBXEKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $107

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    25 mg

    $160

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    50 mg

    $292

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    100 mg

    $477

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    Product Description

    Fursultiamine is a synthetic derivative of vitamin B1 (thiamine; Item No. 25332).1 It reduces LPS-induced increases in IL-6, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) protein levels and decreases in mitochondrial respiration in ARPE-19 retinal pigment epithelial cells when used at concentrations of 100 and 20 µM, respectively.2 Fursultiamine (50 mg/kg) also reduces the area and severity of laser-induced lesions in a mouse model of choroidal neovascularization (CNV). It increases thiamine levels in various rat tissues, including skeletal muscle and the heart, and prevents physical-fatigue loading decreases in skeletal muscle ATP levels induced by forced swimming with a weight load in rats when administered at a dose of 50 mg/kg.3 Fursultiamine (100 mg/kg) enhances the protective effects of glucosamine and chondroitin sulfate on cartilage lesion formation in a rabbit model of osteoarthritis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kobayashi, T., Notoya, K., Nakamura, A., et al. Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. Inflamm. Res. 54(6), 249-255 (2005).

    2. Do, J.Y., Kim, J., Kim, M.-J., et al. Fursultiamine alleviates choroidal neovascularization by suppressing inflammation and metabolic reprogramming. Invest. Ophthalmol. Vis. Sci. 61(12), 24 (2020).

    3. Nozaki, S., Mizuma, H., Tanaka, M., et al. Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats. Nutr. Res. 29(12), 867-872 (2009).