An internal standard for the quantification of biperiden
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Biperiden-d5

Item No. 33469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-bicyclo[2.2.1]hept-5-en-2-yl-(α-phenyl-d5)-1-piperidinepropanol
CAS Number
2938691-75-7
Molecular Formula
C21H24D5NO
Formula Weight
316.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
OC(CCN1CCCCC1)(C2CC3C=CC2C3)C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
InChi Code
InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2/i1D,3D,4D,7D,8D
InChi Key
YSXKPIUOCJLQIE-DYVTXVBDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $356

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    5 mg

    $1,240

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    Product Description

    Biperiden-d5 is intended for use as an internal standard for the quantification of biperiden by GC- or LC-MS. Biperiden is an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.48, 6.3, 3.9, 2.4, and 6.3 nM for M1-5 receptors, respectively).1 It increases spontaneous and electrically evoked dopamine release and electrically evoked acetylcholine (ACh) release from rabbit caudate nucleus slices preincubated with dopamine.2 Biperiden (10 µM) also inhibits NMDA-induced ACh release in rabbit caudate nucleus slices.3 Biperiden (0.01-1.0 mg/kg) reduces physostigmine-induced tremor in rats.4 Formulations containing biperiden have been used as an adjuvant treatment for Parkinson's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bolden, C., Cusack, B., and Richelson, E. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J. Pharmacol. Exp. Ther. 260(2), 576-580 (1992).

    2. Jackisch, R., Huang, H.Y., Reimann, W., et al. Effects of the antiparkinsonian drug budipine on neurotransmitter release in central nervous system tissue in vitro. J. Pharmacol. Exp. Ther. 264(2), 889-898 (1993).

    3. Jackisch, R., Kruchen, A., Sauermann, W., et al. The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists. Eur. J. Pharmacol. 264(2), 207-211 (1994).

    4. Gothóni, P., Lehtinen, M., and Fincke, M. Drugs for Parkinson’s disease reduce tremor induced by physostigmine. Naunyn Schmiedebergs Arch. Pharmacol. 323(3), 205-210 (1983).