An amino acid and a precursor in NMDA biosynthesis
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D-Aspartic Acid

Item No. 33494

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1783-96-6
Synonyms
  • NSC 97922
Molecular Formula
C4H7NO4
Formula Weight
133.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC(C[C@@H](N)C(O)=O)=O
InChi Code
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChi Key
CKLJMWTZIZZHCS-UWTATZPHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 g

    $36

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    25 g

    $62

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    50 g

    $110

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    100 g

    $169

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    Product Description

    D-Aspartic acid is an amino acid and a precursor in the biosynthesis of NMDA.1,2 It is formed from L-aspartic acid by aspartate racemase and degraded by D-aspartate oxidase (DDO).3,4 It is also produced by degradation of dietary proteins or by intestinal microbiota.4 D-Aspartic acid binds to the L-glutamate site of ionotropic NMDA receptors (Ki = 1.6 µM).5 It increases the production of cAMP in rat synaptosomes when used at a concentration of 1 mM. D-Aspartic acid enhances electrically stimulated field excitatory postsynaptic potentials (fEPSPs) in rat hippocampal slices following administration in the drinking water at a concentration of 20 mM.6 It increases serum levels of growth hormone, luteinizing hormone, testosterone, and progesterone (Item No. 15876) in rats.7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, G., and Sun, H.J. Racemization in reverse: Evidence that D-amino acid toxicity on Earth is controlled by bacteria with racemases. PLoS One 9(3), e92101 (2014).

    2. D'Aniello, S., Fisher, G.H., Topo, E., et al. N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum. BMC Neurosci. 8, 109 (2007).

    3. D'Aniello, S., Somorjai, I., Garcia-Fernàndez, J., et al. D-Aspartic acid is a novel endogenous neurotransmitter. The FASEB Journal 25(3), 1014-1027 (2011).

    4. Usiello, A., Di Fiore, M.M., De Rosa, A., et al. New evidence on the role of D-aspartate metabolism in regulating brain and endocrine system physiology: From preclinical observations to clinical applications. Int. J. Mol. Sci. 21(22), 8718 (2020).

    5. Fagg, G.E., and Matus, A. Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities. Proc. Natl. Acad. Sci. USA 81(21), 6876-6880 (1984).

    6. Errico, F., Nisticò, R., Palma, G., et al. Increased levels of ᴅ-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Mol. Cell Neurosci. 37(2), 236-246 (2008).

    7. D'Aniello, A., Di Fiore, M.M., Fisher, G.H., et al. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. The FASEB Journal 14(5), 699-714 (2000).