An inhibitor of PDGF-induced activity and an antiplatelet agent
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Trapidil

Item No. 33496

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-α]pyrimidin-7-amine
CAS Number
15421-84-8
Synonyms
  • Triazolopyrimidine
Molecular Formula
C10H15N5
Formula Weight
205.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
306 nm
SMILES
CCN(CC)C1=CC(C)=NC2=NC=NN21
InChi Code
InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3
InChi Key
GSNOZLZNQMLSKJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $263

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    50 mg

    $363

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    Product Description

    Trapidil is an inhibitor of PDGF-induced activity and an antiplatelet agent.1,2 It inhibits PDGF-induced proliferation of U251MG glioma cells and isolated rat aortic smooth muscle cells in a concentration-dependent manner. Trapidil (1 mM) inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), or U-46619 (Item No. 16450) in washed isolated human platelets.3 It reduces increases in intimal thickness and prevents restenosis induced by balloon angioplasty in rabbits fed a high-cholesterol diet when administered at a dose of 30 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuratsu, J., and Ushio, Y. Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro. J. Neurosurg. 73(3), 436-440 (1990).

    2. Hoshiya, M., and Awazu, M. Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension 31(2), 665-671 (1998).

    3. Mazurov, A.V., Yu, M., Leytin, V.L., et al. Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil. FEBS Lett. 172(2), 167-171 (1984).

    4. Liu, M.W., Roubin, G.S., Robinson, K.A., et al. Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation 81(3), 1089-1093 (1990).