A non-steroidal ERβ agonist
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AC-186

Item No. 33526

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-phenol
CAS Number
1421854-16-1
Molecular Formula
C18H17F3O
Formula Weight
306.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
230 nm
SMILES
FC1(F)CCC(C2=CC=C(O)C=C2)(C3=CC=CC=C3F)CC1
InChi Code
InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2
InChi Key
HSMUKSLNDJOZQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $283

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    Product Description

    AC-186 is a non-steroidal estrogen receptor β (ERβ) agonist (EC50 = 6 nM in a functional assay).1 It is selective for ERβ over ERα (EC50 = 5,000 nM). AC-186 (10 mg/kg) reduces dopaminergic neuronal loss in the substantia nigra, improves novel object recognition, and improves motor performance in male, but not female, rats in a model of Parkinson’s disease induced by 6-OHDA (Item No. 25330). It reduces tactile allodynia in male, but not female or female ovariectomized, rats in a model of spinal nerve ligation-induced neuropathic pain.2 AC-186 (10 and 30 mg/kg) also reduces tactile allodynia in male rats in a model of neuropathic pain induced by paclitaxel (Item No. 10461).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McFarland, K., Price, D.L., Davis, C.N., et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson’s disease rat model. ACS Chem. Neurosci. 4(9), 1249-1255 (2013).

    2. Ma, J.-N., McFarland, K., Olsson, R., et al. Estrogen receptor beta selective agonists as agents to treat chemotherapeutic-induced neuropathic pain. ACS Chem. Neurosci. 7(9), 1180-1187 (2016).