An internal standard for the quantification of midodrine
Related Products
Unlabeled Version(s)
17349Midodrine (hydrochloride)
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Midodrine-d6 (hydrochloride)

Item No. 33546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-[2-[2,5-di(methoxy-d3)phenyl]-2-hydroxyethyl]-acetamide, monohydrochloride
CAS Number
1188265-43-1
Molecular Formula
C12H12D6N2O4 • HCl
Formula Weight
296.8
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
NCC(NCC(C1=C(C=CC(OC([2H])([2H])[2H])=C1)OC([2H])([2H])[2H])O)=O.Cl
InChi Code
InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H/i1D3,2D3;
InChi Key
MGCQZNBCJBRZDT-TXHXQZCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $112

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    1 mg

    $212

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    5 mg

    $889

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    Product Description

    Midodrine-d6 is intended for use as an internal standard for the quantification of midodrine (Item No. 17349) by GC- or LC-MS. Midodrine is a prodrug form of the α1-adrenergic receptor (α1-AR) agonist desglymidodrine.1 It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats.2 Formulations containing midodrine have been used in the treatment of orthostatic hypotension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McClellan, K.J., Wiseman, L.R., and Wilde, M.I. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging 12(1), 76-86 (1998).

    2. Dabasaki, T., Shimojo, M., Ishikawa, H., et al. Anti-hypotensive effects of M6434, an orally active α1-adrenoceptor agonist, in rats. Jpn. J. Pharmacol. 59(2), 145-150 (1992).