A prodrug form of desglymidodrine
Related Products
Active Metabolite(s)
35608Desglymidodrine
Labeled Version(s)
33546Midodrine-d6 (hydrochloride)
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Midodrine (hydrochloride)

Item No. 17349

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide, monohydrochloride
CAS Number
43218-56-0
Molecular Formula
C12H18N2O4 • HCl
Formula Weight
290.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mlDMSO: 10 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
290 nm
SMILES
OC(CNC(CN)=O)C1=C(OC)C=CC(OC)=C1.Cl
InChi Code
InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
InChi Key
MGCQZNBCJBRZDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $37

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    100 mg

    $70

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    250 mg

    $162

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    Product Description

    Midodrine is a prodrug form of the α1-adrenergic receptor (α1-AR) agonist desglymidodrine (Item No. 35608).1 It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats.2 Formulations containing midodrine have been used in the treatment of orthostatic hypotension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McClellan, K.J., Wiseman, L.R., and Wilde, M.I. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging 12(1), 76-86 (1998).

    2. Dabasaki, T., Shimojo, M., Ishikawa, H., et al. Anti-hypotensive effects of M6434, an orally active α1-adrenoceptor agonist, in rats. Jpn. J. Pharmacol. 59(2), 145-150 (1992).