A synthetic peptide substrate
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RR-Src (trifluoroacetate salt)

Item No. 33579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-arginyl-L-leucyl-L-isoleucyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-tyrosyl-L-alanyl-L-alanyl-L-arginyl-glycine, trifluoroacetate salt
Synonyms
  • Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly
  • RRLIEDAEYAARG
  • Src-Peptide
Molecular Formula
C64H106N22O21 • XCF3COOH
Formula Weight
1519.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C64H106N22O21.C2HF3O2/c1-8-31(4)49(86-60(106)42(26-30(2)3)83-55(101)39(14-11-25-74-64(70)71)81-53(99)37(65)12-9-23-72-62(66)67)61(107)82-41(20-22-46(90)91)57(103)85-44(28-47(92)93)59(105)78-34(7)52(98)80-40(19-21-45(88)89)56(102)84-43(27-35-15-17-36(87)18-16-35)58(104)77-32(5)50(96)76-33(6)51(97)79-38(13-10-24-73-63(68)69)54(100)75-29-48(94)95;3-2(4,5)1(6)7/h15-18,30-34,37-44,49,87H,8-14,19-29,65H2,1-7H3,(H,75,100)(H,76,96)(H,77,104)(H,78,105)(H,79,97)(H,80,98)(H,81,99)(H,82,107)(H,83,101)(H,84,102)(H,85,103)(H,86,106)(H,88,89)(H,90,91)(H,92,93)(H,94,95)(H4,66,67,72)(H4,68,69,73)(H4,70,71,74);(H,6,7)/t31-,32-,33-,34-,37-,38-,39-,40-,41-,42-,43-,44-,49-;/m0./s1
InChi Key
OSZFOKWAQDVJJB-YQYPCEDLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    RR-Src is a synthetic peptide substrate that corresponds to the sequence in Src surrounding the tyrosine subject to phosphorylation.1,2 It is a substrate for EGF-mediated tyrosine phosphorylation.3 RR-Src inhibits IL-2-induced proliferation of cytotoxic T cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casnellie, J.E., Harrison, M.L., Pike, L.J., et al. Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. Proc. Natl. Acad. Sci. USA 79(2), 282-286 (1982).

    2. Pike, L.J., Gallis, B., Casnellie, J.E., et al. Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. Proc. Natl. Acad. Sci. USA 79(5), 1443-1447 (1982).

    3. Cassel, D., Pike, L.J., Grant, G.A., et al. Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrate. The Journal of Biological Chemisty 258(5), 2945-2950 (1983).

    4. Taffs, R.E., and Sitkovsky, M.V. Modulation of the effector functions of cytolytic T-lymphocytes with synthetic peptide inhibitors of protein kinases. J. Pharm. Sci. 81(1), 37-44 (1992).