A bacterial metabolite with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N,N'-Diphenethylurea

Item No. 33580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-bis(2-phenylethyl)-urea
CAS Number
5467-84-5
Synonyms
  • 1,3-Diphenethylurea
  • NSC 25433
Molecular Formula
C17H20N2O
Formula Weight
268.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 1 mg/ml
SMILES
O=C(NCCC1=CC=CC=C1)NCCC2=CC=CC=C2
InChi Code
InChI=1S/C17H20N2O/c20-17(18-13-11-15-7-3-1-4-8-15)19-14-12-16-9-5-2-6-10-16/h1-10H,11-14H2,(H2,18,19,20)
InChi Key
VMQLWVGHPWFHEI-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $115

    Add

    25 mg

    $263

    Add

    50 mg

    $493

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    N,N’-Diphenethylurea is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1 It inhibits Streptomyces chitin synthase 1 (IC50 = 14 µg/ml) but not C. albicans chitin synthase 2 when used at concentrations up to 280 µg/ml. N,N’-Diphenethylurea is active against the fungus C. neoformans and the plant pathogenic fungus R. solani (MIC = 50 µg/ml for both).2 It enhances insulin-induced adipocyte differentiation in 3T3-L1 and C3H/10T1/2 cells when used at concentrations of 30 and 100 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwai, Y., Hirano, A., Awaya, J., et al. 1,3-Diphenethylurea from Streptomyces sp. No. AM-2498. J. Antibiot. (Tokyo) 31(4), 375-376 (1978).

    2. Kim, N.R., Hwang, E.I., Bong, S.K., et al. Isolation of Candida albicans chitin synthase 1 inhibitor from Steptomyces sp. A6705 and its characterization. J. Microbiol. Biotechnol. 15(4), 895-898 (2005).

    3. Choi, S.-S., Cha, B.-Y., Kagami, I., et al. N,N'-diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-L1 cells. J. Antibiot. (Tokyo) 64(3), 277-280 (2011).