A synthetic peptide agonist of FPR1 and FPR2
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WKYMVm (trifluoroacetate salt)

Item No. 33589

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide, trifluoroacetate salt
Synonyms
  • Trp-Lys-Tyr-Met-Val-D-Met
Molecular Formula
C41H61N9O7S2 • XCF3COOH
Formula Weight
856.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
219 nm
SMILES
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C41H61N9O7S2.C2HF3O2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30;3-2(4,5)1(6)7/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55);(H,6,7)/t29-,31+,32-,33-,34-,35-;/m0./s1
InChi Key
MYVYQWVNXDVTBW-HQORXVKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $379

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    10 mg

    $615

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    25 mg

    $1,183

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    WKYMVm is a synthetic peptide agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).1,2,3 It induces calcium mobilization in ETFR rat basophilic leukemia cells transfected with FPR1 or FPR2 when used at a concentration of 0.1 nM.1 WKYMVm stimulates chemotaxis of monocytes, dendritic cells, and natural killer (NK) cells, as well as induces superoxide production in monocytes and neutrophils, in vitro.3 In vivo, WKYMVm (8 mg/kg) reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of colitis induced by dextran sulfate (sodium salt) (DSS; Item No. 23250). Topical application of WKYMVm stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Le, Y., Gong, W., Li, B., et al. Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J. Immunol. 163(12), 6777-6784 (1999).

    2. Kwon, Y.W., Heo, S.C., Jang, I.H., et al. Stimulation of cutaneous wound healing by an FPR2-specific peptide agonist WKYMVm. Wound Repair Regen. 23(4), 575-582 (2015).

    3. Kim, S.D., Kwon, S., Lee, S.K., et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp. Mol. Med. 45(9), e40 (2013).