Octahydrocurcumin

Octahydrocurcumin is an active metabolite of curcumin (Item Nos. 81025 | 81025.1) that has diverse biological activities.^1,2,3,4 It scavenges DPPH radicals in a cell-free assay (IC₅₀ = 12.3 µM).¹ Octahydrocurcumin (6.25 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, production of nitric oxide (NO), and nuclear translocation of NF-ᴋB in RAW 264.7 cells.² It is active against the bacteria B. subtilis, K. pneumoniae, E. coli, E. aerogenes, P. aeruginosa, and S. aureus, as well as C. albicans, in disc assays.³ Octahydrocurcumin (5, 10, and 20 mg/kg) increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model.⁴

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1. Deters, M., Knochenwefel, H., Lindhorst, D., et al. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm. Res. 25(8), 1822-1827 (2008).

2. Zhao, F., Gong, Y., Hu, Y., et al. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Mol. Med. Rep. 11(4), 3087-3093 (2015).

3. Singh, R.P., and Jain, D.A. Antimicrobial activity of hydrogenated derivatives of curcumin. Pharm. Res. 5(7), 3650-3653 (2012).

4. Zhang, Z., Luo, D., Xie, J., et al. Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosis. Food Funct. 9(4), 2005-2014 (2018).