A dual agonist of PPARα and PPARγ
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KRP 297

Item No. 33699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2,4-dioxo-5-thiazolidinyl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]-benzamide
CAS Number
213252-19-8
Synonyms
  • MK-767
Molecular Formula
C20H17F3N2O4S
Formula Weight
438.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
COC(C(C(NCC1=CC=C(C(F)(F)F)C=C1)=O)=C2)=CC=C2CC3C(NC(S3)=O)=O
InChi Code
InChI=1S/C20H17F3N2O4S/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28)
InChi Key
NFFXEUUOMTXWCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $317

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    10 mg

    $515

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    Cayman Chemical
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    Product Description

    KRP 927 is a thiazolidinedione dual agonist of PPARα and PPARγ (EC50s = 149 and 83 nM, respectively, in transactivation assays).1 It decreases hyperglycemia and hyperinsulinemia in ob/ob mice in a dose-dependent manner. KRP 927 (10 or 30 mg/kg) reduces serum total cholesterol and triglyceride levels in hamsters.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Doebber, T.W., Kelly, L.J., Zhou, G., et al. MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities. Biochem. Biophys. Res. Commun. 318(2), 323-328 (2004).