An active metabolite of chlorpromazine
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Parent Compound(s)
16129Chlorpromazine (hydrochloride)
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7-hydroxy Chlorpromazine (hydrochloride)

Item No. 33729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-3-ol, monohydrochloride
CAS Number
51938-11-5
Molecular Formula
C17H19ClN2OS • HCl
Formula Weight
371.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
ClC1=CC=C2SC3=CC(O)=CC=C3N(CCCN(C)C)C2=C1.Cl
InChi Code
InChI=1S/C17H19ClN2OS.ClH/c1-19(2)8-3-9-20-14-6-5-13(21)11-17(14)22-16-7-4-12(18)10-15(16)20;/h4-7,10-11,21H,3,8-9H2,1-2H3;1H
InChi Key
OTIORHLXOLCOAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    2.5 mg

    $419

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    Product Description

    7-hydroxy Chlorpromazine is an active metabolite of the typical antipsychotic chlorpromazine (Item No. 16129).1 In vivo, 7-hydroxy chlorpromazine (5 mg/kg) increases plasma prolactin levels in male rats. It also reverses D-amphetamine-induced depression of the dopaminergic neuronal firing rate in the rat substantia nigra in rats when administered at a dose of 1.6 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meltzer, H.Y., Fang, V.S., Simonovich, M., et al. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats. Eur. J. Pharmacol. 41(4), 431-436 (1977).

    2. Bunney, B.S., and Aghajanian, G.K. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sci. 15(2), 309-318 (1974).