Active • Host: HEK293 cells • AA: 2-201 (full length) • Tag: N-terminal human IgG1 Fc • MW: 49.5 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cardiotrophin-1 (human, recombinant)

Item No. 33733

Product Insert (PDF)
Technical Information
Synonyms
  • CT-1
  • CT1
  • CTF1
Purity
≥80% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Active recombinant N-terminal human IgG1 Fc-tagged cardiotrophin-1 expressed in HEK293 cells
Amino Acids
2-201
MW
49.5 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
Q16619
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $422

    Add

    1 mg

    $2,738

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Cardiotrophin-1 is a glycosylated polypeptide and member of the IL-6 family of cytokines.1 It is composed of four α-helices but lacks the hydrophobic N-terminal secretion signal sequence that most IL-6 family proteins contain.2 Cardiotrophin-1 is primarily expressed in embryonic and adult cardiomyocytes, but it is also expressed in skeletal muscle, as well as the liver, lungs, and kidneys.1,3 Its expression is increased under cellular stress conditions, such as hypoxic stress.1 Cardiotrophin-1 forms a heterocomplex with gp130 and leukemia inhibitory factor receptor β (LIFRβ) in cardiomyocytes and, in other cells, with gp130, LIFRβ, and cytokine-specific α-chains, which signal through the JAK/STAT, ERK/MAPK, and PI3K/AKT pathways. It induces cardiomyocyte hypertrophy in vitro, and levels of cardiotrophin-1 are increased in the heart in animal models after myocardial infarction and protect the heart from ischemic injury.1 Serum levels of cardiotrophin-1 are increased in patients with heart failure and hypertensive disease.2 It has both protective or detrimental effects in various tissues, including the heart, kidney, and vasculature.3,1 Cayman’s Cardiotrophin-1 (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of cardiotrophin-1 (amino acids 2-201) fused to human IgG1 at its N-terminus, consists of 460 amino acids and has a calculated molecular weight of 49.5 kDa. As a result of glycosylation, the monomer migrates at approximately 54 kDa by SDS-PAGE under reducing conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. García-Cenador, M.B., Lopez-Novoa, J.M., Díez, J., et al. Effects and mechanism of organ protection by cardiotrophin-1. Curr. Med. Chem. 20(2), 246-256 (2013).

    2. López-Yoldi, M., Moreno-Aliaga , M.J., and Bustos, M. Cardiotrophin-1: A multifaceted cytokine. Cytokine Growth Factor Rev. 26(5), 523-532 (2015).

    3. Asrih, M., Mach, F., Quercioli, A., et al. Update on the pathophysiological activities of the cardiac molecule cardiotrophin-1 in obesity. Mediators Inflamm. 2013, 370715 (2013).