A monoterpene with diverse biological activities
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Carvacrol

Item No. 33753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-5-(1-methylethyl)-phenol
CAS Number
499-75-2
Synonyms
  • Cymophenol
  • Isopropyl o-cresol
  • NSC 6188
  • p-Cymen-2-ol
Molecular Formula
C10H14O
Formula Weight
150.2
Purity
≥98%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/ml
SMILES
OC1=CC(C(C)C)=CC=C1C
InChi Code
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
InChi Key
RECUKUPTGUEGMW-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

    $33

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    100 g

    $63

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    250 g

    $148

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    500 g

    $213

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    Product Description

    Carvacrol is a monoterpene that has been found in O. vulgare, and has diverse biological activities.1 It induces currents in HEK293 cells expressing mouse transient receptor potential vanilloid 3 (TRPV3) or rat TRP ankyrin A1 (TRPA1) when used at concentrations of 500 and 250 µM, respectively.2 It also inhibits constitutive activation of TRP melastatin 7 (TRPM7) expressed in HEK293 cells (IC50 = 306 µM).3 Carvacrol is active against various strains of P. aeruginosa (MICs = 0.3-0.13 µg/ml) and a variety of plant pathogenic fungi, including A. niger, A. ochraceus, Cladosporium, and F. oxysporum (MICs = 50, 100, 100, and 125 µg/ml, respectively).4,5. It decreases rat brain, liver, and kidney levels of malondialdehyde (MDA), as well as increases superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), and catalase activities in the same tissues when administered at a dose of 40 mg/kg.6 Carvacrol (15 mg/kg) decreases the number of liver tumor nodules in a rat model of diethylnitrosamine-induced hepatocarcinogenesis.7 Formulations containing carvacrol have been used as flavoring agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharifi-Rad, M., Varoni, E.M., Iriti, M., et al. Carvacrol and human health: A comprehensive review. Phytother. Res. 32(9), 1675-1687 (2018).

    2. Xu, H., Delling, M., Jun, J.C., et al. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci. 9(5), 628-635 (2006).

    3. Parnas, M., Peters, M., Dadon, D., et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45(3), 300-309 (2009).

    4. Cox, S.D., and Markham, J.L. Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compounds. J. Appl. Microbiol. 103(4), 930-936 (2007).

    5. Abbaszadeh, S., Sharifzadeh, A., Shokri, H., et al. Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. J. Mycol. Med. 24(2), e51-e56 (2014).

    6. Samarghandian, S., Farkhonden, T., Samini, F., et al. Protective effects of carvacrol against oxidative stress induced by chronic stress in rat’s brain, liver, and kidney. Biochem. Res. Int. 2645237 (2016).

    7. Jayakumar, S., Madankumar, A., Asokkumar, S., et al. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Mol. Cell Biochem. 360(1-2), 51-60 (2012).