A ZIP7 inhibitor
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NVS-ZP7-4

Item No. 33773

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4′(1′H)-quinazolin]-2′(3′H)-one
CAS Number
2349367-89-9
Molecular Formula
C28H28FN5OS
Formula Weight
501.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
227, 256 nm
SMILES
O=C1NC2(CCN(CC2)C[C@H](CC3=CC=CC=C3)NC4=NC5=CC=C(F)C=C5S4)C6=CC=CC=C6N1
InChi Code
InChI=1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1
InChi Key
FZOFDZMKSAUTHT-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).1 It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin (Item No. 17754) in MDA-MB-231 and RCC4 cells when used at a concentration of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nolin, E., Gans, S., Llamas, L., et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat. Chem. Biol. 15(2), 179-188 (2019).

    2. Chen, P.-H., Wu, J., Xu, Y., et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 12(2), 198 (2021).