An NRP-1/VEGF-A interaction inhibitor
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CAY10781

Item No. 33778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-4-oxo-2-(3-pyridinyl)-5-pyrimidineacetic acid
CAS Number
1210360-87-4
Molecular Formula
C11H9N3O3
Formula Weight
231.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 10 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
288 nm
SMILES
O=C(CC1=CN=C(C2=CN=CC=C2)NC1=O)O
InChi Code
InChI=1S/C11H9N3O3/c15-9(16)4-8-6-13-10(14-11(8)17)7-2-1-3-12-5-7/h1-3,5-6H,4H2,(H,15,16)(H,13,14,17)
InChi Key
PQXHMOPMDOFJHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $69

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    50 mg

    $273

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    100 mg

    $478

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    250 mg

    $1,023

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    Product Description

    CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1 It inhibits the interaction by 43% when used at a concentration of 12.5 µM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perez-Miller, S., Patek, M., Moutal, A., et al. In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein. bioRxiv 308783 (2020).