An inhibitor of p38α MAPK
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MW-150

Item No. 33789

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-pyridazine
CAS Number
1628502-91-9
Synonyms
  • MW01-18-150SRM
Molecular Formula
C24H23N5
Formula Weight
381.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
λmax
217, 232, 274 nm
SMILES
CN(CC1)CCN1C2=CC(C3=CC=NC=C3)=C(C4=CC5=C(C=CC=C5)C=C4)N=N2
InChi Code
InChI=1S/C24H23N5/c1-28-12-14-29(15-13-28)23-17-22(19-8-10-25-11-9-19)24(27-26-23)21-7-6-18-4-2-3-5-20(18)16-21/h2-11,16-17H,12-15H2,1H3
InChi Key
CIIVUDIZZJLXCN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    MW-150 is an inhibitor of p38α MAPK (Ki = 101 nM).1 It is 6-, 10-, and 14-fold selective for p38α MAPK over the serine/threonine protein kinase NLK, p38β MAPK, and p38δ MAPK, respectively, and is also selective over the enzymatically normal mutant p38α MAPKT106M. It inhibits p38α MAPK phosphorylation of the endogenous substrate MAPK-activated protein kinase 2 (MK2) in LPS-activated glia in a concentration-dependent manner and decreases the levels of IL-1β in the same cells. MW-150 (2.5 mg/kg per day, i.p.) reduces the number of errors made in the spatial reference memory version of the radial arm water maze in aged amyloid precursor protein/presenilin 1 (APP/PS1) knock-in mice as a model of Alzheimer’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roy, S.M., Grum-Tokars, V.L., Schavocky, J.P., et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer’s disease mouse models. ACS Chem. Neurosci. 6(4), 666-680 (2015).