An internal standard for the quantification of enrofloxacin
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Unlabeled Version(s)
20301Enrofloxacin
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Enrofloxacin-d5

Item No. 33809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-7-[4-(ethyl-1,1,2,2,2-d5)-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS Number
1173021-92-5
Synonyms
  • BAY-Vp 2674-d5
  • ENR-d5
Molecular Formula
C19H17D5FN3O3
Formula Weight
364.4
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 1 mg/ml
λmax
284 nm
SMILES
O=C1C2=CC(F)=C(N3CCN(CC3)C([2H])([2H])C([2H])([2H])[2H])C=C2N(C4CC4)C=C1C(O)=O
InChi Code
InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)/i1D3,2D2
InChi Key
SPFYMRJSYKOXGV-ZBJDZAJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin (Item No. 20301) by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic.1 It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml).2 Enrofloxacin inhibits bacterial DNA gyrase.3 In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model of enteropathogenic E. coli-induced sepsis. Formulations containing enrofloxacin have been used in the treatment of veterinary bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Randall, L., Ridley, A., Lemma, F., et al. In vitro investigations into the use of antimicrobials in combination to maintain efficacy of fluoroquinolones in poultry. Res. Vet. Sci. 108, 47-53 (2016).

    2. Pereira, C.E.R., Resende, T.P., Vasquez, E., et al. In vitro antimicrobial activity against equine Lawsonia intracellularis strains. Equine Vet. J. 51(5), 665-668 (2019).

    3. Slate, A.R., Bandyopadhyay, S., Francis, K.P., et al. Efficacy of enrofloxacin in a mouse model of sepsis. J. Am. Assoc. Lab. Anim. Sci. 53(4), 381-386 (2014).