An internal standard for the quantification of triamterene
Related Products
Unlabeled Version(s)
21242Triamterene
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Triamterene-d5

Item No. 33815

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-phenyl-d5-2,4,7-pteridinetriamine
CAS Number
1189922-23-3
Synonyms
  • 2,4,7-Triamino-6-phenylpteridine-d5
Molecular Formula
C12H6D5N7
Formula Weight
258.3
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
NC1=NC(N)=NC2=C1N=C(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])C(N)=N2
InChi Code
InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)/i1D,2D,3D,4D,5D
InChi Key
FNYLWPVRPXGIIP-RALIUCGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $297

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    Product Description

    Triamterene-d5 is intended for use as an internal standard for the quantification of triamterene (Item No. 21242) by GC- or LC-MS. Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 µM for the rat channel).1 In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats.2 Formulations containing triamterene have been used in the treatment of edema.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kellenberger, S., Gautschi, I., and Schlid, L. Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol. Pharmacol. 64(4), 848-856 (2003).

    2. Baba, W.I., Tudhope, G.R., and Wilson, G.M. Triamterene, a new diuretic drug. I. Studies in normal men and in adrenalectomized rats. Br. Med. J. 2(5307), 756-760 (1962).