An ENaC inhibitor
Related Products
Analytical Standard(s)
22486Triamterene
Labeled Version(s)
33815Triamterene-d5
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Triamterene

Item No. 21242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-phenyl-2,4,7-pteridinetriamine
CAS Number
396-01-0
Synonyms
  • NSC 77625
  • SKF 8542
  • 2,4,7-Triamino-6-phenylpteridine
Molecular Formula
C12H11N7
Formula Weight
253.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
λmax
232, 271, 367 nm
SMILES
NC1=NC(N)=NC(N=C2N)=C1N=C2C3=CC=CC=C3
InChi Code
InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChi Key
FNYLWPVRPXGIIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $22

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    5 g

    $48

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    Product Description

    Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 µM for the rat channel).1 In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats.2 Formulations containing triamterene have been used in the treatment of edema. This product is also available as an analytical reference standard (Item No. 22486).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kellenberger, S., Gautschi, I., and Schlid, L. Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol. Pharmacol. 64(4), 848-856 (2003).

    2. Baba, W.I., Tudhope, G.R., and Wilson, G.M. Triamterene, a new diuretic drug. I. Studies in normal men and in adrenalectomized rats. Br. Med. J. 2(5307), 756-760 (1962).