Meglutol

Meglutol is an HMG-CoA reductase inhibitor (IC₅₀ = 4 nM) and antimetabolite of mevalonic acid.¹ Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.² It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.³ Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.⁴ Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.⁴

WARNING This product is not for human or veterinary use.

1. Medina-Franco, J.L., López-Vallejo, F., Rodríguez-Morales, S., et al. Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductase. Bioorg. Med. Chem. Lett. 15(4), 989-994 (2005).

2. Beg, Z.H., and Siddiqi, M. Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acid. Experientia 23(5), 380 (1967).

3. Lupien, P.J., Tremblay, M., and Beg, Z.H. 3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbits. Atherosclerosis 18(3), 407-416 (1973).

4. da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al. 3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brain. Neurotox. Res. 37(2), 314-325 (2020).