The lactone form of rosuvastatin
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Rosuvastatin lactone

Item No. 33885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide
CAS Number
503610-43-3
Synonyms
  • (+)-Rosuvastatin lactone
  • Rosuvastatin-5S-lactone
  • RSTL
Molecular Formula
C22H26FN3O5S
Formula Weight
463.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: Slightly soluble
λmax
245 nm
SMILES
O[C@@H](CC(O1)=O)C[C@H]1/C=C/C2=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C2C3=CC=C(C=C3)F
InChi Code
InChI=1S/C22H26FN3O5S/c1-13(2)20-18(10-9-17-11-16(27)12-19(28)31-17)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)32(4,29)30/h5-10,13,16-17,27H,11-12H2,1-4H3/b10-9+/t16-,17-/m1/s1
InChi Key
SOEGVMSNJOCVHT-VEUZHWNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $248

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    50 mg

    $363

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    Product Description

    Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin (Item No. 18813).1 It is found in vivo following rosuvastatin administration.2 Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 µM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shiozawa, A., Yamaori, S., Kamijo, S., et al. Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3). Drug Metab. Pharmacokinet. 36, 100364 (2021).

    2. Martin, P.D., Warwick, M.J., Dane, A.L., et al. Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers. Clin. Ther. 25(11), 2822-2835 (2003).