An amino acid and a precursor in L-carnitine biosynthesis

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Product Type

Biochemicals

Amino Acids

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Cell Biology

Mitochondrial Biology

N^ε,N^ε,N^ε-Trimethyllysine (chloride)

Name: Nε,Nε,Nε-Trimethyllysine (chloride)
Brand: -

Item No. 33898

Nε,Nε,Nε-Trimethyllysine (chloride) (TML, N6-Trimethyllysine, Nε-Trimethyllysine, CAS Number: 55528-53-5)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

5-amino-5-carboxy-N,N,N-trimethyl-1-pentanaminium, monochloride

CAS Number

55528-53-5

Synonyms

TML
N⁶-Trimethyllysine
N^ε-Trimethyllysine

Molecular Formula

C₉H₂₁N₂O₂ • Cl

Formula Weight

224.7

Purity

≥95%

Formulation (Request formulation change)

A solid

Solubility(Learn about Variance in Solubility)

PBS (pH 7.2): 1 mg/ml

SMILES

C[N+](C)(C)CCCC[C@H](N)C(O)=O.[Cl-]

InChi Code

InChI=1S/C9H20N2O2.ClH/c1-11(2,3)7-5-4-6-8(10)9(12)13;/h8H,4-7,10H2,1-3H3;1H/t8-;/m0./s1

InChi Key

ZKIJKCHCMFGMCM-QRPNPIFTSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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5 mg

$36

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10 mg

$68

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25 mg

$103

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Product Description

N^ε,N^ε,N^ε-Trimethyllysine is an amino acid and a precursor in the biosynthesis of L-carnitine (Item No. 21489).¹ It is produced by intestinal microbiota or can be obtained by the degradation of post-translationally modified proteins or dietary sources.^2,3

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Strijbis, K., Vaz, F.M., and Distel, B. Enzymology of the carnitine biosynthesis pathway. IUBMB Life 62(5), 357-362 (2010).

2. Zhao, M., Zhao, L., Xiong, X., et al. TMAVA, a metabolite of intestinal microbes, is increased in plasma from patients with liver steatosis, inhibits γ-butyrobetaine hydroxylase, and exacerbates fatty liver in mice. Gastroenterology 158(8), 2266-2281 (2020).

3. Servillo, L., Giovane, A., Cautela, D., et al. Where does Nε-trimethyllysine for the carnitine biosynthesis in mammals come from? PLoS One 9(1), e84589 (2014).

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